Abstract / Description: 

Lower extremity peripheral artery disease (PAD) burden differs by race/ethnicity. Although familial aggregation and heritability studies suggest a genetic basis, little is known about the genetic susceptibility to PAD, especially in non-European descent populations. Genome-wide association studies (GWAS) of the ankle brachial index (ABI) and PAD (defined as an ABI?<?0.90) have not been conducted in Hispanics/Latinos. We performed a GWAS of PAD and the ABI in 7,589 participants aged >45 years from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We also performed GWAS for ABI stratified by Hispanic/Latino ethnic subgroups: Central American, Mexican, and South American (Mainland group), and Cuban, Dominican, and Puerto Rican (Caribbean group). We detected two genome-wide significant associations for the ABI in COMMD10 in Puerto Ricans, and at SYBU in the Caribbean group. The lead SNP rs4466200 in the COMMD10 gene had a replication p?=?0.02 for the ABI in Multi-Ethnic Study of Atherosclerosis (MESA) African Americans, but it did not replicate in African Americans from the Cardiovascular Health Study (CHS). In a regional look-up, a nearby SNP rs12520838 had Bonferroni adjusted p?=?0.05 (unadjusted p?=?7.5?◊?10-5) for PAD in MESA Hispanics. Among three suggestive associations (p?<?10-7) in subgroup-specific analyses, DMD on chromosome X, identified in Central Americans, replicated in MESA Hispanics (p?=?2.2?◊?10-4). None of the previously reported ABI and PAD associations in whites generalized to Hispanics/Latinos.

eCardio Hub Collection
Sofer T1,2, Emery L3, Jain D3, Ellis AM4, Laurie CC3, Allison MA5, Lee J6, Kurniansyah N6, Kerr KF3, Gonz·lez HM7, Tarraf W8, Criqui MH5, Lange LA9, Palmas WR10, Franceschini N11, Wassel CL12.